Endocrine Abstracts

We report new estimates of the disutility associated with GL and PL, and the quality of life (QoL) impact of leptin replacement therapy (LRT) based on two methods. The first approach estimates utility decrements associated with a range of impairments related to lipodystrophy through a discrete choice experiment (DCE) conducted with members of the general public; the second elicits QoL estimates from 8 PL patients using the SF-36 instrument. To characterize QoL consequences of ...

Introduction: Adrenal insufficiency is rare in the neonatal period and if unrecognised may cause life-threatening circulatory collapse. The initial investigations taken at the time of presentation, and prior to the institution of hydrocortisone, are a key step in the diagnostic pathway, and aid the clinician to distinguish adrenal insufficiency from mineralocorticoid resistance or renal tubulopathy. A cortisol measurement at the time of illness is useful to evaluate the adrena...

Injected depot formulations of somatostatin peptide analogs are routinely used to treat acromegaly and neuroendocrine tumors (NETs). Paltusotine (CRN00808), a small molecule nonpeptide selective somatostatin receptor 2 (sst2) agonist, is being evaluated for efficacy and safety in patients with acromegaly. The current Phase 1 study (NCT04246749) was conducted in two Parts: In Part A, the absorption, metabolism, excretion, and mass balance of a single oral dose of 20 mg [14C]-pa...

Introduction: The stress response post-operatively increases glucocorticoid concentration and a higher cortisol response is associated with better recovery. The measurement of cortisol concentrations post-operatively can be unreliable due to altered binding protein concentrations. Free serum cortisol is felt to be the better marker of bio-active glucocorticoid concentrations but is difficult to measure. Salivary cortisol and cortisone have been shown to correlate well with ser...

Glucocorticoids are known to have a role in the programming of appetite regulation but the mechanisms have not been fully delineated. This study examined the effect of maternal undernutrition on glucocorticoid receptor (GR) as a key regulator of the appetite regulating neuropeptides, proopiomelanocortin (POMC) and neuropeptide Y (NPY) in the hypothalamus.Ewes were undernourished (UN, n=4) for 30 days pre- and 60 days post-mating or given normal fe...

Maternal undernutrition influences the development of diseases such as obesity and diabetes in the adult offspring. Programming of key genes involved in hypothalamic appetite regulation such as proopiomelanocortin (POMC) and neuropeptide Y (NPY) may affect energy balance in adulthood. These changes may occur by alterations in gene expression or epigenetic changes including histone acetylation and DNA methylation. This study aims to examine the effects of maternal undernutritio...

Introduction: Hyponatraemia is a common biochemical abnormality in hospital patients, a robust management plan and correct diagnosis is important in the medical care of these patients. However these are frequently lacking.Methods: We audited the management and outcomes of hyponatraemia in a large district general hospital. In-patients for a period of 3 months starting from January 2004 with hyponatraemia (Sodium less than reference rang 132-146 mmol per ...

Background: Nutritional data in NETs is lacking. There are a range of gastrointestinal issues which can be related to the NET, treatment, surgical intervention, or pre-existing diseases1. Many of these can have nutritional consequences or be improved through altering diet with the support of a specialist dietitian.From October 2018, a gastrointestinal specialist dietitian joined the weekly clinic for 12 months. The aim of the service evaluatio...

Glucocorticoids (Gc) are potent anti-inflammatory steroids which mediate their effects by binding the glucocorticoid receptor (GR). Following ligand binding, GR initiates rapid ‘non-genomic’ kinase signals in the cytoplasm, then translocates into the nucleus to mediate ‘genomic’ effects by binding DNA directly or tethering to other DNA bound transcription factors to modulate target gene expression. Little is known about how rapidly induced cytoplasm derived...

Ageing is associated with sarcopenia, osteoporosis and an increased risk of falling, which together contribute to increased fracture risk. There are few data describing the associations between functional measures of muscle and bone during ageing. Therefore, the aim of this study was to examine in ageing men associations between measures of lower-limb muscle strength and age and then to investigate the relationships with tibial bone outcomes.Men (n</...